Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SRC-2 Coactivator Deficiency Decreases Functional Reserve in Response to Pressure Overload of Mouse Heart

31 Dec 2012

Abstract excerpt

A major component of the cardiac stress response is the simultaneous activation of several gene regulatory networks. Interestingly, the transcriptional regulator steroid receptor coactivator-2, SRC-2 is often decreased during cardiac failure in humans. We postulated that SRC-2 suppression plays a mechanistic role in the stress response and that SRC-2 activity is an important regulator of the adult heart gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Cardiovascular Function and Risk Factors
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23300926
DOI: 10.1371/journal.pone.0053395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SRC-2 Coactivator Deficiency Decreases Functional Reserve in Response to Pressure Overload of Mouse HeartPMID 23300926Read ↗

Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity.Semantic proximity Read ↗

Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart FailureSemantic proximity Read ↗

Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action.Semantic proximity Read ↗

The MEF2D transcription factor mediates stress-dependent cardiac remodeling in miceSemantic proximity Read ↗

Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure.Semantic proximity Read ↗

Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.Semantic proximity Read ↗

Exercise assessment of transgenic models of human cardiovascular diseaseSemantic proximity Read ↗

Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload.Semantic proximity Read ↗

A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload.Semantic proximity Read ↗

Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial FunctionSemantic proximity Read ↗

Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression.Semantic proximity Read ↗

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.