Article
Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.
The American journal of pathology - 1 Dec 2015
Gan Xiaohong T, Rajapurohitam Venkatesh, Xue Jenny, Huang Cathy, Bairwa Suresh, Tang Xilan, Chow Jeffrey T-Y, Liu Melissa F W, Chiu Felix, Sakamoto Kazuhito, Wagner Kay-Uwe, Karmazyn Morris
Abstract excerpt
The Janus kinase (JAK) system is involved in numerous cell signaling processes and is highly expressed in cardiac tissue. The JAK isoform JAK2 is activated by numerous factors known to influence cardiac function and pathologic conditions. However, although abundant, the role of JAK2 in the regulation or maintenance of cardiac homeostasis remains poorly understood. Using the Cre-loxP system, we generated a...
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