Article
Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure.
Physiological genomics - 21 Sept 2005
Rothermel Beverly A, Berenji Kambeez, Tannous Paul, Kutschke William, Dey Asim, Nolan Bridgid, Yoo Ki-Dong, Demetroulis Elaine, Gimbel Michael, Cabuay Barry, Karimi Mohsen, Hill Joseph A
Abstract excerpt
Hypertrophic growth of the myocardium occurs in most forms of heart failure and may contribute to the pathogenesis of the failure state. Little is known about the regulatory mechanisms governing the often-coexisting phenotypes of hypertrophy, systolic failure, and diastolic stiffness that characterize clinical disease. We hypothesized that intracellular signaling pathways are differentially activated by graded...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.