Article
Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression.
Proceedings of the National Academy of Sciences of the United States of America - 16 Feb 1999
Qi C, Zhu Y, Pan J, Yeldandi A V, Rao M S, Maeda N, Subbarao V, Pulikuri S, Hashimoto T, Reddy J K
Abstract excerpt
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors, and it is assumed that the biological effects of these receptors depend on interactions with recently identified coactivators, including steroid receptor coactivator-1 (SRC-1). We assessed the in vivo function of SRC-1 on the PPARalpha-regulated gene expression in liver by generating mice in which the SRC-1 gene was...
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