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Article

A Gaussia luciferase cell-based system to assess the infection of cell culture- and serum-derived hepatitis C virus.

PloS one - 1 Jan 2012

Koutsoudakis George, Pérez-del-Pulgar Sofía, González Patricia, Crespo Gonzalo, Navasa Miquel, Forns Xavier

Abstract excerpt

Robust replication of hepatitis C virus (HCV) in cell culture occurs only with the JFH-1 (genotype 2a) recombinant genome. The aim of this study was to develop a system for HCV infection quantification analysis and apply it for the selection of patient sera that may contain cell culture infectious viruses, particularly of the most clinically important genotype 1. Initially, a hepatoma cell line (designated...

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Source

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Identifiers

PMID: 23300900
DOI: 10.1371/journal.pone.0053254
PMCID: PMC3534054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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