Article
A new system to measure and compare hepatitis C virus replication capacity using full-length, replication competent viruses.
Journal of virological methods - 1 Dec 2013
Lassmann Britta, Arumugaswami Vaithilingaraja, Chew Kara W, Lewis Martha J
Abstract excerpt
Measuring the in vitro replication capacity of viruses is an important tool for assessing the effects of selective pressure of immune responses and drug therapy. Measuring hepatitis C virus (HCV) replication capacity utilizing primarily sub-genomic reporter constructs is limited. To overcome some of these limitations a quantitative reverse transcriptase PCR (RT-qPCR) was designed to measure simultaneously the...
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