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Detection of Hepatitis C Virus Infection from Patient Sera in Cell Culture Using Semi-Automated Image Analysis.

Viruses - 30 Nov 2024

Schäfer Noemi, Rothhaar Paul, Heuss Christian, Neumann-Haefelin Christoph, Thimme Robert, Dietz Julia, Sarrazin Christoph, Schnitzler Paul, Merle Uta, Pérez-Del-Pulgar Sofía, Laketa Vibor, Lohmann Volker

Abstract excerpt

The study of hepatitis C virus (HCV) replication in cell culture is mainly based on cloned viral isolates requiring adaptation for efficient replication in Huh7 hepatoma cells. The analysis of wild-type (WT) isolates was enabled by the expression of SEC14L2 and by inhibitors targeting deleterious host factors. Here, we aimed to optimize cell culture models to allow infection with HCV from patient sera. We used...

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PMID: 39772180
DOI: 10.3390/v16121871

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