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A subclone of HuH-7 with enhanced intracellular hepatitis C virus production and evasion of virus related-cell cycle arrest.

PloS one - 1 Jan 2012

Murayama Asako, Sugiyama Nao, Yoshimura Seiko, Ishihara-Sugano Mitsuko, Masaki Takahiro, Kim Sulyi, Wakita Takaji, Mishiro Shunji, Kato Takanobu

Abstract excerpt

Hepatitis C virus (HCV) cell culture system with JFH-1 strain and HuH-7 cells enabled us to produce infectious HCV particles in vitro, and such system is useful to explore the anti-HCV compounds and to develop the vaccine against HCV. In the present study, we describe the derivation of a cell line that permits improved production of HCV particles. Specifically, we characterized several subclones that were...

Topics

Cell Cycle Checkpoints
Cell Line
Gene Expression Regulation
Genotype
Hepacivirus
Humans
Viral Load
Virus Replication

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23285155
DOI: 10.1371/journal.pone.0052697
PMCID: PMC3527576

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