Robust hepatitis E virus infection and transcriptional response in human hepatocytes.

doi:10.1073/pnas.1912307117

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Article

Robust hepatitis E virus infection and transcriptional response in human hepatocytes.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 2020

Todt Daniel, Friesland Martina, Moeller Nora, Praditya Dimas, Kinast Volker, Brüggemann Yannick, Knegendorf Leonard, Burkard Thomas, Steinmann Joerg, Burm Rani, Verhoye Lieven, Wahid Avista, Meister Toni Luise, Engelmann Michael, Pfankuche Vanessa M, Puff Christina, Vondran Florian W R, Baumgärtner Wolfgang, Meuleman Philip, Behrendt Patrick, Steinmann Eike

Abstract excerpt

Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and the leading cause for acute viral hepatitis worldwide. The virus is classified as a member of the genus Orthohepevirus A within the Hepeviridae family. Due to the absence of a robust cell culture model for HEV infection, the analysis of the viral life cycle, the development of effective antivirals and a vaccine is severely limited. In...

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Identifiers

PMID: 31896581
DOI: 10.1073/pnas.1912307117
PMCID: PMC6983376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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