Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes.

PLoS pathogens - 1 Dec 2012

Elis Efrat, Ehrlich Marcelo, Prizan-Ravid Adi, Laham-Karam Nihay, Bacharach Eran

Abstract excerpt

The p12 protein of the murine leukemia virus (MLV) is a constituent of the pre-integration complex (PIC) but its function in this complex remains unknown. We developed an imaging system to monitor MLV PIC trafficking in live cells. This allowed the visualization of PIC docking to mitotic chromosomes and its release upon exit from mitosis. Docking occurred concomitantly with nuclear envelope breakdown and was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Capsid
Share to Capsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, gag

Share to Leukemia Virus, Murine

Share to Nuclear Envelope

Share to Virus Attachment

Share to Virus Integration

Source

Open in PubMed Open full text

Identifiers

PMID: 23300449
DOI: 10.1371/journal.ppat.1003103
PMCID: PMC3531515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes.PMID 23300449Read ↗

Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis.Semantic proximity Read ↗

The Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex.Semantic proximity Read ↗

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag.Semantic proximity Read ↗

Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12.Semantic proximity Read ↗

The N-terminus of murine leukaemia virus p12 protein is required for mature core stability.Semantic proximity Read ↗

Phosphorylation Requirement of Murine Leukemia Virus p12.Semantic proximity Read ↗

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry.Semantic proximity Read ↗

Viral Genome Tethering to Host Cell Chromatin: Cause and ConsequencesSemantic proximity Read ↗

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA IntegrationSemantic proximity Read ↗

HIV-1 uncoats in the nucleus near sites of integrationSemantic proximity Read ↗

Targeting mitotic chromosomes: a conserved mechanism to ensure viral genome persistenceSemantic proximity Read ↗

Factors that mold the nuclear landscape of HIV-1 integrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.