Article
A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry.
PLoS pathogens - 1 May 2017
Aydin Inci, Villalonga-Planells Ruth, Greune Lilo, Bronnimann Matthew P, Calton Christine M, Becker Miriam, Lai Kun-Yi, Campos Samuel K, Schmidt M Alexander, Schelhaas Mario
Abstract excerpt
Incoming papillomaviruses (PVs) depend on mitotic nuclear envelope breakdown to gain initial access to the nucleus for viral transcription and replication. In our previous work, we hypothesized that the minor capsid protein L2 of PVs tethers the incoming vDNA to mitotic chromosomes to direct them into the nascent nuclei. To re-evaluate how dynamic L2 recruitment to cellular chromosomes occurs specifically during...
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