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Article

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag.

Proceedings of the National Academy of Sciences of the United States of America - 4 Jun 2013

Schneider William M, Brzezinski Jonathon D, Aiyer Sriram, Malani Nirav, Gyuricza Mercedes, Bushman Frederic D, Roth Monica J

Abstract excerpt

The p12 protein of murine leukemia virus (MuLV) group-specific antigen (Gag) is associated with the preintegration complex, and mutants of p12 (PM14) show defects in nuclear entry or retention. Here we show that p12 proteins engineered to encode peptide sequences derived from known viral tethering proteins can direct chromatin binding during the early phase of viral replication and rescue a lethal p12-PM14...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, gag

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Share to Leukemia Virus, Murine

Share to Oncogene Proteins, Viral

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Source

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Identifiers

PMID: 23661057
DOI: 10.1073/pnas.1221736110
PMCID: PMC3677494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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