Article
The N-terminus of murine leukaemia virus p12 protein is required for mature core stability.
PLoS pathogens - 1 Oct 2014
Wight Darren J, Boucherit Virginie C, Wanaguru Madushi, Elis Efrat, Hirst Elizabeth M A, Li Wilson, Ehrlich Marcelo, Bacharach Eran, Bishop Kate N
Abstract excerpt
The murine leukaemia virus (MLV) gag gene encodes a small protein called p12 that is essential for the early steps of viral replication. The N- and C-terminal regions of p12 are sequentially acting domains, both required for p12 function. Defects in the C-terminal domain can be overcome by introducing a chromatin binding motif into the protein. However, the function of the N-terminal domain remains unknown. Here,...
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