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Article

Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12.

Journal of virology - 15 Dec 2016

Brzezinski Jonathon D, Modi Apexa, Liu Mengdan, Roth Monica J

Abstract excerpt

Murine leukemia virus (MLV) p12, encoded within Gag, binds the viral preintegration complex (PIC) to the mitotic chromatin. This acts to anchor the viral PIC in the nucleus as the nuclear envelope re-forms postmitosis. Mutations within the p12 C terminus (p12 PM13 to PM15) block early stages in viral replication. Within the p12 PM13 region (p12 60PSPMA65), our studies indicated that chromatin tethering was not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27707926
DOI: 10.1128/JVI.01084-16
PMCID: PMC5126376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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