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Article

The Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex.

PLoS pathogens - 11 Nov 2010

Prizan-Ravid Adi, Elis Efrat, Laham-Karam Nihay, Selig Sara, Ehrlich Marcelo, Bacharach Eran

Abstract excerpt

The p12 protein is a cleavage product of the Gag precursor of the murine leukemia virus (MLV). Specific mutations in p12 have been described that affect early stages of infection, rendering the virus replication-defective. Such mutants showed normal generation of genomic DNA but no formation of circular forms, which are markers of nuclear entry by the viral DNA. This suggested that p12 may function in early...

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Share to Chromosomes, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Experimental

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Source

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Identifiers

PMID: 21085616
DOI: 10.1371/journal.ppat.1001183
PMCID: PMC2978732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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