Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis.

PLoS pathogens - 1 Jun 2018

Wanaguru Madushi, Barry David J, Benton Donald J, O'Reilly Nicola J, Bishop Kate N

Abstract excerpt

The murine leukaemia virus (MLV) Gag cleavage product, p12, is essential for both early and late steps in viral replication. The N-terminal domain of p12 binds directly to capsid (CA) and stabilises the mature viral core, whereas defects in the C-terminal domain (CTD) of p12 can be rescued by addition of heterologous chromatin binding sequences (CBSs). We and others hypothesised that p12 tethers the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Chromatin
Share to Gene Products, gag

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitosis

Share to Nucleosomes

Share to Virion

Share to Virus Assembly

Share to Virus Integration

Source

Open in PubMed Open full text

Identifiers

PMID: 29906285
DOI: 10.1371/journal.ppat.1007117
PMCID: PMC6021111

Genes

CBS
CPSF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis.PMID 29906285Read ↗

p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes.Semantic proximity Read ↗

Repression of the Chromatin-Tethering Domain of Murine Leukemia Virus p12.Semantic proximity Read ↗

Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag.Semantic proximity Read ↗

The Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex.Semantic proximity Read ↗

The N-terminus of murine leukaemia virus p12 protein is required for mature core stability.Semantic proximity Read ↗

Phosphorylation Requirement of Murine Leukemia Virus p12.Semantic proximity Read ↗

Chromatin tethering of incoming foamy virus by the structural Gag protein.Semantic proximity Read ↗

Viral Genome Tethering to Host Cell Chromatin: Cause and ConsequencesSemantic proximity Read ↗

Factors that mold the nuclear landscape of HIV-1 integrationSemantic proximity Read ↗

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA IntegrationSemantic proximity Read ↗

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry.Semantic proximity Read ↗

Atomic structure of the Epstein-Barr virus portalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.