Article
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.
Human genetics - 1 Apr 2013
Siedlinski Mateusz, Tingley Dustin, Lipman Peter J, Cho Michael H, Litonjua Augusto A, Sparrow David, Bakke Per, Gulsvik Amund, Lomas David A, Anderson Wayne, Kong Xiangyang, Rennard Stephen I, Beaty Terri H, Hokanson John E, Crapo James D, Lange Christoph, Silverman Edwin K
Abstract excerpt
Cigarette smoking is the major environmental risk factor for chronic obstructive pulmonary disease (COPD). Genome-wide association studies have provided compelling associations for three loci with COPD. In this study, we aimed to estimate direct, i.e., independent from smoking, and indirect effects of those loci on COPD development using mediation analysis. We included a total of 3,424 COPD cases and 1,872...
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