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Article

Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine - 15 Dec 2010

Pillai Sreekumar G, Kong Xiangyang, Edwards Lisa D, Cho Michael H, Anderson Wayne H, Coxson Harvey O, Lomas David A, Silverman Edwin K

Abstract excerpt

RATIONALE: Genome-wide association studies have shown significant associations between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the disease mechanisms behind these associations are not well understood. OBJECTIVES: To identify the association between...

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Source

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Identifiers

PMID: 20656943
DOI: 10.1164/rccm.201002-0151OC
PMCID: PMC3029936

Genes

HHIP
CHRNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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