Article
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
BMC genetics - 3 Dec 2015
Lutz Sharon M, Cho Michael H, Young Kendra, Hersh Craig P, Castaldi Peter J, McDonald Merry-Lynn, Regan Elizabeth, Mattheisen Manuel, DeMeo Dawn L, Parker Margaret, Foreman Marilyn, Make Barry J, Jensen Robert L, Casaburi Richard, Lomas David A, Bhatt Surya P, Bakke Per, Gulsvik Amund, Crapo James D, Beaty Terri H, Laird Nan M, Lange Christoph, Hokanson John E, Silverman Edwin K
Abstract excerpt
BACKGROUND: Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with...
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