Article
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
Human molecular genetics - 15 Feb 2012
Cho Michael H, Castaldi Peter J, Wan Emily S, Siedlinski Mateusz, Hersh Craig P, Demeo Dawn L, Himes Blanca E, Sylvia Jody S, Klanderman Barbara J, Ziniti John P, Lange Christoph, Litonjua Augusto A, Sparrow David, Regan Elizabeth A, Make Barry J, Hokanson John E, Murray Tanda, Hetmanski Jacqueline B, Pillai Sreekumar G, Kong Xiangyang, Anderson Wayne H, Tal-Singer Ruth, Lomas David A, Coxson Harvey O, Edwards Lisa D, MacNee William, Vestbo Jørgen, Yates Julie C, Agusti Alvar, Calverley Peter M A, Celli Bartolome, Crim Courtney, Rennard Stephen, Wouters Emiel, Bakke Per, Gulsvik Amund, Crapo James D, Beaty Terri H, Silverman Edwin K
Abstract excerpt
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown. To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies. We performed a GWAS using a total of 3499 cases and 1922 control subjects from four cohorts: the...
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