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Article

Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2013

Gadel Sarah, Crafford Amanda, Regina Karen, Kharasch Evan D

Abstract excerpt

The long-acting opioid methadone displays considerable unexplained interindividual pharmacokinetic variability. Methadone metabolism clinically occurs primarily by N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), catalyzed predominantly by CYP2B6. Retrospective studies suggest that the common allele variant CYP2B6*6 may influence methadone plasma concentrations. The catalytic activity of...

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Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Isoenzymes

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Share to Microsomes, Liver

Share to Oxidoreductases, N-Demethylating

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Source

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Identifiers

PMID: 23298862
DOI: 10.1124/dmd.112.050625
PMCID: PMC3608451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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