Article
The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jun 2013
Li Yibai, Coller Janet K, Hutchinson Mark R, Klein Kathrin, Zanger Ulrich M, Stanley Nathan J, Abell Andrew D, Somogyi Andrew A
Abstract excerpt
Ketamine is primarily metabolized to norketamine by hepatic CYP2B6 and CYP3A4-mediated N-demethylation. However, the relative contribution from each enzyme remains controversial. The CYP2B6*6 allele is associated with reduced enzyme expression and activity that may lead to interindividual variability in ketamine metabolism. We examined the N-demethylation of individual ketamine enantiomers using human liver...
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