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Article

Structure based energy calculation to determine the regulation of G protein signalling by RGS and RGS-G protein interaction specificity.

Interdisciplinary sciences, computational life sciences - 1 Sept 2012

Gulati Gavish, Gaonkar Krutika Satish, Kamraj Balu, Kumar Ambuj, Purohit Rituraj

Abstract excerpt

The RGS proteins act as GTPase activating proteins and therefore regulate the lifespan of the active G alpha-GTP by accelerating the GTP hydrolysis. Modulatory residues in the RGS protein are present at the periphery of the RGS domain-G protein interface which is essential to fine-tune the G protein recognition and interaction. The docking energies of the mutant complex and the native complex were compared to see...

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Source

Identifiers

PMID: 23292690
DOI: 10.1007/s12539-012-0130-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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