Article
Structural and functional analysis of the regulator of G protein signaling 2-gαq complex.
Structure (London, England : 1993) - 5 Mar 2013
Nance Mark R, Kreutz Barry, Tesmer Valerie M, Sterne-Marr Rachel, Kozasa Tohru, Tesmer John J G
Abstract excerpt
The heterotrimeric G protein Gαq is a key regulator of blood pressure, and excess Gαq signaling leads to hypertension. A specific inhibitor of Gαq is the GTPase activating protein (GAP) known as regulator of G protein signaling 2 (RGS2). The molecular basis for how Gαq/11 subunits serve as substrates for RGS proteins and how RGS2 mandates its selectivity for Gαq is poorly understood. In crystal structures of the...
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