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Article

"Disruptor" residues in the regulator of G protein signaling (RGS) R12 subfamily attenuate the inactivation of Gα subunits.

Science signaling - 12 Jun 2018

Asli Ali, Sadiya Isra, Avital-Shacham Meirav, Kosloff Mickey

Abstract excerpt

Understanding the molecular basis of interaction specificity between RGS (regulator of G protein signaling) proteins and heterotrimeric (αβγ) G proteins would enable the manipulation of RGS-G protein interactions, explore their functions, and effectively target them therapeutically. RGS proteins are classified into four subfamilies (R4, R7, RZ, and R12) and function as negative regulators of G protein signaling...

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Share to GTP-Binding Protein alpha Subunits
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29895615
DOI: 10.1126/scisignal.aan3677

Genes

RGS18
RGS10
RGS14

Provenance

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