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Article

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF.

The Journal of biological chemistry - 14 Mar 2003

Chen Zhe, Singer William D, Wells Clark D, Sprang Stephen R, Sternweis Paul C

Abstract excerpt

Structural requirements for function of the Rho GEF (guanine nucleotide exchange factor) regulator of G protein signaling (rgRGS) domains of p115RhoGEF and homologous exchange factors differ from those of the classical RGS domains. An extensive mutagenesis analysis of the p115RhoGEF rgRGS domain was undertaken to determine its functional interface with the Galpha(13) subunit. Results indicate that there is global...

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Source

Identifiers

PMID: 12525488
DOI: 10.1074/jbc.M212695200

Genes

RGS4
RGS9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF.PMID 12525488Read ↗

Structure of the rgRGS domain of p115RhoGEF.Semantic proximity Read ↗

Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.Semantic proximity Read ↗

Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF.Semantic proximity Read ↗

Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.Semantic proximity Read ↗

Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits.Semantic proximity Read ↗

"Disruptor" residues in the regulator of G protein signaling (RGS) R12 subfamily attenuate the inactivation of Gα subunits.Semantic proximity Read ↗

Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins.Semantic proximity Read ↗

Characterization of the GRK2 binding site of Galphaq.Semantic proximity Read ↗

Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF.Semantic proximity Read ↗

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Semantic proximity Read ↗

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