Article
Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins.
Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997
Druey K M, Kehrl J H
Abstract excerpt
Regulators of G protein signaling (RGS) proteins limit the lifetime of activated (GTP-bound) heterotrimeric G protein a subunits by acting as GTPase-activating proteins (GAPs). Mutation of two residues in RGS4, which, based on the crystal structure of RGS4 complexed with G(i alpha1)-GDP-AIF4-, directly contact G(i alpha1) (N88 and L159), essentially abolished RGS4 binding and GAP activity. Mutation of another...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.