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Article

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

DNA repair - 1 Aug 2007

Kaina Bernd, Christmann Markus, Naumann Steffen, Roos Wynand P

Abstract excerpt

O(6)-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate, among other lesions, O(6)-alkylguanine in DNA (collectively termed O(6)-alkylating agents [O(6)AA]). The defense is highly important, since O(6)AA are common environmental carcinogens, are formed endogenously during normal cellular metabolism and possibly inflammation, and are being used in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17485253
DOI: 10.1016/j.dnarep.2007.03.008

Genes

MGMT
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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