Article
IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).
Mutation research. Genetic toxicology and environmental mutagenesis - 1 May 2015
MacGregor James T, Frötschl Roland, White Paul A, Crump Kenny S, Eastmond David A, Fukushima Shoji, Guérard Melanie, Hayashi Makoto, Soeteman-Hernández Lya G, Kasamatsu Toshio, Levy Dan D, Morita Takeshi, Müller Lutz, Schoeny Rita, Schuler Maik J, Thybaud Véronique, Johnson George E
Abstract excerpt
This report summarizes the discussion, conclusions, and points of consensus of the IWGT Working Group on Quantitative Approaches to Genetic Toxicology Risk Assessment (QWG) based on a meeting in Foz do Iguaçu, Brazil October 31-November 2, 2013. Topics addressed included (1) the need for quantitative dose-response analysis, (2) methods to analyze exposure-response relationships & derive point of departure (PoD)...
Topics
- DNA
- Humans
- Models, Genetic
- Mutagenicity Tests
- Mutagens
- Mutation
- Neoplasms
- Risk Assessment