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Article

Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells.

G3 (Bethesda, Md.) - 2 Mar 2018

Duncan Christopher G, Kondilis-Mangum Hrisavgi D, Grimm Sara A, Bushel Pierre R, Chrysovergis Kaliopi, Roberts John D, Tyson Frederick L, Merrick B Alex, Wade Paul A

Abstract excerpt

The DNA methyltransferase, Dnmt3a, is dynamically regulated throughout mammalian B cell development and upon activation by antigenic stimulation. Dnmt3a inactivation in hematopoietic stem cells has been shown to drive B cell-related malignancies, including chronic lymphocytic leukemia, and associates with specific DNA methylation patterns in transformed cells. However, while it is clear that inactivation of...

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PMID: 29326230
DOI: 10.1534/g3.117.300446
PMCID: PMC5844302

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