Experimental myasthenia gravis in Aire-deficient mice: a link between Aire and regulatory T cells.

doi:10.1111/j.1749-6632.2012.06843.x

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Article

Experimental myasthenia gravis in Aire-deficient mice: a link between Aire and regulatory T cells.

Annals of the New York Academy of Sciences - 1 Dec 2012

Aricha Revital, Feferman Tali, Berrih-Aknin Sonia, Fuchs Sara, Souroujon Miriam C

Abstract excerpt

Aire (autoimmune regulator) has a key role in the establishment of tolerance to autoantigens. Aire(-/-) mice present decreased thymic expression of AChR, significantly lower frequencies of regulatory T (T(reg)) cells, and higher expression of Th17 markers, compared to controls. We therefore predicted that Aire(-/-) mice would be more susceptible to induction of experimental autoimmune myasthenia gravis (EAMG)....

Topics

Aging
Animals
Genetic Predisposition to Disease
Mice
Mice, Knockout
Myasthenia Gravis
T-Lymphocytes, Regulatory
Transcription Factors
AIRE Protein

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Open in PubMed

Identifiers

PMID: 23278585
DOI: 10.1111/j.1749-6632.2012.06843.x

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