Article
AIRE deficiency, from preclinical models to human APECED disease.
Disease models & mechanisms - 5 Feb 2021
Besnard Marine, Padonou Francine, Provin Nathan, Giraud Matthieu, Guillonneau Carole
Abstract excerpt
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare life-threatening autoimmune disease that attacks multiple organs and has its onset in childhood. It is an inherited condition caused by a variety of mutations in the autoimmune regulator (AIRE) gene that encodes a protein whose function has been uncovered by the generation and study of Aire-KO mice. These provided invaluable...
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