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Article

The development of mouse APECED models provides new insight into the role of AIRE in immune regulation.

Clinical & developmental immunology - 1 Sept 2005

Pereira Lara E, Bostik Pavel, Ansari Aftab A

Abstract excerpt

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy is a rare recessive autoimmune disorder caused by a defect in a single gene called AIRE (autoimmune regulator). Characteristics of this disease include a variable combination of autoimmune endocrine tissue destruction, mucocutaneous candidiasis and ectodermal dystrophies. The development of Aire-knockout mice has provided an invaluable model for the...

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Identifiers

PMID: 16295527
DOI: 10.1080/17402520500212589
PMCID: PMC2275420

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The development of mouse APECED models provides new insight into the role of AIRE in immune regulation.PMID 16295527Read ↗

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Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome.Semantic proximity Read ↗

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APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility FactorsSemantic proximity Read ↗

Expression and function of the autoimmune regulator (Aire) gene in non-thymic tissueSemantic proximity Read ↗

Where AIRE we now? Where AIRE we going?Semantic proximity Read ↗

Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease.Semantic proximity Read ↗

Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED).Semantic proximity Read ↗

Disruption of immunological tolerance: role of AIRE gene in autoimmunity.Semantic proximity Read ↗

The autoimmune regulator: a key toward understanding the molecular pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.Semantic proximity Read ↗

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