Article
AIRE expands: new roles in immune tolerance and beyond.
Nature reviews. Immunology - 1 Apr 2016
Anderson Mark S, Su Maureen A
Abstract excerpt
More than 15 years ago, mutations in the autoimmune regulator (AIRE) gene were identified as the cause of autoimmune polyglandular syndrome type 1 (APS1). It is now clear that this transcription factor has a crucial role in promoting self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the...
Topics
- Autoantigens
- Autoimmune Diseases
- Humans
- Immune Tolerance
- Mutation
- Polyendocrinopathies, Autoimmune
- Self Tolerance
- T-Lymphocytes, Regulatory
- Transcription Factors
- AIRE Protein