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Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)

19 Sept 2017

Abstract excerpt

Autoimmunity is prevented by the function of the autoimmune regulator [AIRE (Aire in mice)], which promotes the expression of a wide variety of tissue-restricted antigens (TRAs) from medullary thymic epithelial cells (mTECs) and from a subset of peripheral antigen-presenting cells (APCs). We examined the effect of additive expression of human AIRE (huAIRE) in a model of autoimmune diabetes in NOD mice....

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PMID: 28931462
DOI: 10.1016/j.jaut.2017.09.006

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