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Article

Disruption of immunological tolerance: role of AIRE gene in autoimmunity.

Autoimmunity reviews - 1 Feb 2006

Rizzi M, Ferrera F, Filaci G, Indiveri F

Abstract excerpt

The mechanism underlying the generation of T and B autoreactive clones in autoimmune diseases is still unknown. Among genetic factors implicated in autoimmunity, Autoimmune Regulator gene (AIRE) is one of the candidates to better understand the complex scenario of autoimmune manifestations. AIRE mutations are responsible for the development of autoimmune polyendocrinopathy candidiasis ectodermal dystrophy...

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Source

Identifiers

PMID: 16431348
DOI: 10.1016/j.autrev.2005.09.001

Genes

AIRE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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