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Article

Where AIRE we now? Where AIRE we going?

Current opinion in allergy and clinical immunology - 1 Dec 2024

Bez Patrick, Ceraudo Martina, Vianello Fabrizio, Rattazzi Marcello, Scarpa Riccardo

Abstract excerpt

PURPOSE OF REVIEW: The purpose of the review is to describe the most recent advancement in understanding of the pivotal role of autoimmune regulator ( AIRE ) gene expression in central and peripheral tolerance, and the implications of its impairment in the genetic and pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) manifestations with insight into possible treatment...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39440452
DOI: 10.1097/ACI.0000000000001041
PMCID: PMC11537476

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Genetic basis of altered central tolerance and autoimmune diseases: a lesson from AIRE mutations.Semantic proximity Read ↗

Update on Aire and thymic negative selection.Semantic proximity Read ↗

Loss of AIRE-Mediated Immune Tolerance and the Skin.Semantic proximity Read ↗

Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease.Semantic proximity Read ↗

Aire deficient mice develop multiple features of APECED phenotype and show altered immune responseSemantic proximity Read ↗

Genotype-Phenotype Delineation of Autoimmune Polyendocrinopathy, Candidiasis, and Ectodermal Dystrophy in a Pediatric Patient: A Case Report.Semantic proximity Read ↗

The autoimmune regulator: a key toward understanding the molecular pathogenesis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.Semantic proximity Read ↗

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