Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

1 Feb 2005

Abstract excerpt

Autoimmune regulator (AIRE) gene mutation is responsible for the development of organ-specific autoimmune disease with monogenic autosomal recessive inheritance. Although Aire has been considered to regulate the elimination of autoreactive T cells through transcriptional control of tissue-specific Ags in thymic epithelial cells, other mechanisms of AIRE-dependent tolerance remain to be investigated. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15699112
DOI: 10.4049/jimmunol.174.4.1862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient MicePMID 15699112Read ↗

AIRE expands: new roles in immune tolerance and beyond.Semantic proximity Read ↗

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)Semantic proximity Read ↗

Recent insights into the role and molecular mechanisms of the autoimmune regulator (AIRE) gene in autoimmunity.Semantic proximity Read ↗

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.Semantic proximity Read ↗

Disruption of immunological tolerance: role of AIRE gene in autoimmunity.Semantic proximity Read ↗

Expression and function of the autoimmune regulator (Aire) gene in non-thymic tissueSemantic proximity Read ↗

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.Semantic proximity Read ↗

Autoimmune regulator and self‐tolerance – molecular and clinical aspectsSemantic proximity Read ↗

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire.Semantic proximity Read ↗

The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription.Semantic proximity Read ↗

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.Semantic proximity Read ↗

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.