Article
Insights into immune tolerance from AIRE deficiency.
Current opinion in immunology - 1 Dec 2017
Proekt Irina, Miller Corey N, Lionakis Michail S, Anderson Mark S
Abstract excerpt
AIRE is a well-established master regulator of central tolerance. It plays an essential role in driving expression of tissue-specific antigens in the thymus and shaping the development of positively selected T-cells. Humans and mice with compromised or absent AIRE function have markedly variable phenotypes that include a range of autoimmune manifestations. Recent evidence suggests that this variability stems from...
Topics
- Animals
- Autoantigens
- Gene Expression Regulation
- Humans
- Immune Tolerance
- Mice
- Phenotype
- Polyendocrinopathies, Autoimmune
- Thymus Gland
- Transcription Factors
- AIRE Protein