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Article

Notch 1 impairs osteoblastic cell differentiation.

Endocrinology - 1 Dec 2003

Sciaudone Maria, Gazzerro Elisabetta, Priest Leah, Delany Anne M, Canalis Ernesto

Abstract excerpt

Notch receptors are single pass transmembrane receptors activated by membrane-bound ligands with a role in cell proliferation and differentiation. As Notch 1 and 2 mRNAs are expressed by osteoblasts and induced by cortisol, we postulated that Notch could regulate osteoblastogenesis. We investigated the effects of retroviral vectors directing the constitutive expression of the Notch 1 intracellular domain...

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Identifiers

PMID: 12960086
DOI: 10.1210/en.2003-0463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Notch 1 impairs osteoblastic cell differentiation.PMID 12960086Read ↗

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Notch Signaling in Osteocytes Differentially Regulates Cancellous and Cortical Bone RemodelingSemantic proximity Read ↗

Alteration of Notch signaling in skeletal development and disease.Semantic proximity Read ↗

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.Semantic proximity Read ↗

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Canonical Notch signaling is required for bone morphogenetic protein-mediated human osteoblast differentiationSemantic proximity Read ↗

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