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Article

Osx-Cre Targets Multiple Cell Types besides Osteoblast Lineage in Postnatal Mice

15 Jan 2014

Abstract excerpt

Osterix (Osx or Sp7) is a zinc-finger-family transcriptional factor essential for osteoblast differentiation in mammals. The Osx-Cre mouse line (also known as Osx1-GFP::Cre) expresses GFP::Cre fusion protein from a BAC transgene containing the Osx regulatory sequence. The mouse strain was initially characterized during embryogenesis, and found to target mainly osteoblast-lineage cells. Because the strain has been...

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PMID: 24454809
DOI: 10.1371/journal.pone.0085161

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