Article
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.
Nature medicine - 1 Mar 2008
Hilton Matthew J, Tu Xiaolin, Wu Ximei, Bai Shuting, Zhao Haibo, Kobayashi Tatsuya, Kronenberg Henry M, Teitelbaum Steven L, Ross F Patrick, Kopan Raphael, Long Fanxin
Abstract excerpt
Postnatal bone marrow houses mesenchymal progenitor cells that are osteoblast precursors. These cells have established therapeutic potential, but they are difficult to maintain and expand in vitro, presumably because little is known about the mechanisms controlling their fate decisions. To investigate the potential role of Notch signaling in osteoblastogenesis, we used conditional alleles to genetically remove...
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