Article
[Effect of mutations imitating the phosphorylation by TRPM7 kinase on the function of the N-terminal domain of tropomodulin].
Biofizika - 1 Jan 2000
Dorovkov M V, Beznosov S N, Shah S, Kotlianskaia L, Kostiukova A S
Abstract excerpt
It has been shown that tropomodulin 1 is phosphorylated at serine and threonine residues by TRPM7 kinase. The phosphorylation sites for TRPM7 kinase in the N-terminal functional domain of tropomodulin 1 have been identified, which include tropomyosin-binding and actin-capping regions. It has been found that the phosphorylation-mimicking mutation T54E resulted in the loss of the capping ability of the N-terminal...
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