Article
Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.
The Journal of biological chemistry - 15 Feb 2013
Hernández-Ortega Sara, Bru Samuel, Ricco Natalia, Ramírez Sara, Casals Núria, Jiménez Javier, Isasa Marta, Crosas Bernat, Clotet Josep
Abstract excerpt
Progression through the G(1) phase of the cell cycle is controlled by diverse cyclin-dependent kinases (CDKs) that might be associated to numerous cyclin isoforms. Given such complexity, regulation of cyclin degradation should be crucial for coordinating progression through the cell cycle. In Saccharomyces cerevisiae, SCF is the only E3 ligase known to date to be involved in G(1) cyclin degradation. Here, we...
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