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Article

The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division.

Cell cycle (Georgetown, Tex.) - 15 Sept 2012

McQueen Jennifer, van Dyk Dewald, Young Barry, Loewen Chris, Measday Vivien

Abstract excerpt

The glycogen synthase kinase-3 homolog, Mck1, has been implicated in many cellular functions, from sporulation to calcium stress response in budding yeast. Here, we report a novel function for Mck1 in the inhibition of Clb2-Cdk1 activity post nuclear division. Clb2-Cdk1, the major mitotic cyclin-Cdk complex in yeast, accumulates before anaphase and must be inhibited in telophase for cells to exit mitosis and...

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Identifiers

PMID: 22918234
DOI: 10.4161/cc.21731
PMCID: PMC3466553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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