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Article

F-box protein specificity for g1 cyclins is dictated by subcellular localization.

PLoS genetics - 1 Jan 2012

Landry Benjamin D, Doyle John P, Toczyski David P, Benanti Jennifer A

Abstract excerpt

Levels of G1 cyclins fluctuate in response to environmental cues and couple mitotic signaling to cell cycle entry. The G1 cyclin Cln3 is a key regulator of cell size and cell cycle entry in budding yeast. Cln3 degradation is essential for proper cell cycle control; however, the mechanisms that control Cln3 degradation are largely unknown. Here we show that two SCF ubiquitin ligases, SCF(Cdc4) and SCF(Grr1),...

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Share to Cell Cycle Checkpoints
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Proteolysis

Share to SKP Cullin F-Box Protein Ligases

Share to Substrate Specificity

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Source

Open in PubMed Open full text

Identifiers

PMID: 22844257
DOI: 10.1371/journal.pgen.1002851
PMCID: PMC3405998

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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F-box protein specificity for g1 cyclins is dictated by subcellular localization.PMID 22844257Read ↗

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