Article
The Cak1p protein kinase is required at G1/S and G2/M in the budding yeast cell cycle.
Genetics - 1 Sept 1997
Sutton A, Freiman R
Abstract excerpt
The CAK1 gene encodes the major CDK-activating kinase (CAK) in budding yeast and is required for activation of Cdc28p for cell cycle progression from G2 to M phase. Here we describe the isolation of a mutant allele of CAK1 in a synthetic lethal screen with the Sit4 protein phosphatase. Analysis o...
Topics
- CDC28 Protein Kinase, S cerevisiae
- Cell Cycle
- Cyclin-Dependent Kinases
- G1 Phase
- G2 Phase
- Genes, Fungal
- Genes, Lethal
- Mutation
- Phosphoprotein Phosphatases
- Phosphorylation
- Precipitin Tests
- Protein Phosphatase 2
- Protein Serine-Threonine Kinases
- Proteins
- RNA, Fungal
- RNA, Messenger
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins