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Article

Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation.

The EMBO journal - 25 Feb 2004

Wolfe Benjamin A, Gould Kathleen L

Abstract excerpt

The Cdc14 family of phosphatases specifically reverses proline-directed phosphorylation events. In Saccharomyces cerevisiae, Cdc14p promotes Cdk1p inactivation at mitotic exit by reversing Cdk1p-dependent phosphorylations. Cdk1p is a proline-directed kinase whose activity is required in all eukaryotes for the transit into mitosis. At mitotic commitment, Cdk1p participates in its own regulation by activating the...

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Identifiers

PMID: 14765109
DOI: 10.1038/sj.emboj.7600103
PMCID: PMC381010

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