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Article

Chromatin marks identify critical cell types for fine mapping complex trait variants.

Nature genetics - 1 Feb 2013

Trynka Gosia, Sandor Cynthia, Han Buhm, Xu Han, Stranger Barbara E, Liu X Shirley, Raychaudhuri Soumya

Abstract excerpt

If trait-associated variants alter regulatory regions, then they should fall within chromatin marks in relevant cell types. However, it is unclear which of the many marks are most useful in defining cell types associated with disease and fine mapping variants. We hypothesized that informative marks are phenotypically cell type specific; that is, SNPs associated with the same trait likely overlap marks in the same...

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Identifiers

PMID: 23263488
DOI: 10.1038/ng.2504
PMCID: PMC3826950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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