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Article

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.

Nature structural & molecular biology - 1 Feb 2013

Filbin Megan E, Vollmar Breanna S, Shi Dan, Gonen Tamir, Kieft Jeffrey S

Abstract excerpt

The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication. Functional studies of the HCV IRES have focused on 80S ribosome formation but have not explored its role after the 80S ribosome is poised at the start codon. Here, we report that mutations of an IRES domain that docks in the 40S subunit's decoding groove cause...

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Identifiers

PMID: 23262488
DOI: 10.1038/nsmb.2465
PMCID: PMC3864654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.PMID 23262488Read ↗

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